Molina P E, Hashiguchi Y, Meijerink W J, Naukam R J, Boxer R, Abumrad N N
Department of Surgery, SUNY, School of Medicine, Stony Brook 11794-8191.
Biochem Biophys Res Commun. 1995 Feb 6;207(1):312-7. doi: 10.1006/bbrc.1995.1189.
The endogenous opiate alkaloid content in tissues from fed, 24 h and 48 h fasted rats was determined. Plasma morphine and codeine concentrations did not change in response to fasting. Morphine levels in the spleen increased 3-fold after 24 h of fasting and were lower than fed rats by 48 h of fasting; no change was detected in spleen codeine levels. Brain morphine levels were elevated 5-fold after 24 h of fasting and were two-fold higher than those of fed rats after 48 h of fasting. Brain codeine levels did not change with fasting. These results indicate that opiate alkaloids are endogenously produced in rodent tissues, particularly in the spleen, liver, and adrenals. The synthesis of morphine, in the spleen and brain, is maximally stimulated after 24 h of fasting, without alterations in tissue codeine synthesis. These suggest differential regulation of the endogenous synthetic pathways of morphine and codeine in response to the stress of fasting.
测定了喂食大鼠、禁食24小时和禁食48小时大鼠组织中的内源性阿片生物碱含量。血浆中吗啡和可待因浓度不受禁食影响。禁食24小时后脾脏中吗啡水平增加3倍，禁食48小时后低于喂食大鼠；脾脏中可待因水平未检测到变化。禁食24小时后大脑中吗啡水平升高5倍，禁食48小时后比喂食大鼠高两倍。大脑中可待因水平不受禁食影响。这些结果表明阿片生物碱在啮齿动物组织中内源性产生，特别是在脾脏、肝脏和肾上腺。禁食24小时后，脾脏和大脑中吗啡的合成受到最大刺激，而组织中可待因合成没有变化。这些表明内源性吗啡和可待因合成途径对禁食应激有不同的调节作用。
