Donnerer J, Cardinale G, Coffey J, Lisek C A, Jardine I, Spector S
J Pharmacol Exp Ther. 1987 Aug;242(2):583-7.
Data on the tissue distribution of morphine and codeine in rat are presented. The concentration of these two opiate alkaloids seems to be distributed uniformly in the cortex, midbrain, pons/medulla and cerebellum. The spinal cord and the adrenal gland have high levels of morphine and codeine and the adrenal has more codeine than morphine. The major fraction of the alkaloids reside in a synaptosomal fraction and are present in tissues as the sulfate conjugate. The levels of morphine in the spinal cord and the urinary excretion of morphine are elevated in the arthritic rat model. We used extracted alkaloid samples from arthritic rats spinal cord for analysis by mass spectrometry and found molecular ions identical with morphine and codeine. The results are discussed in the light of possible physiological roles of endogenous morphine and codeine.
本文给出了大鼠体内吗啡和可待因的组织分布数据。这两种阿片生物碱在皮质、中脑、脑桥/延髓和小脑中的浓度似乎分布均匀。脊髓和肾上腺中吗啡和可待因的含量较高，且肾上腺中的可待因比吗啡更多。生物碱的主要部分存在于突触体部分，并以硫酸盐共轭物的形式存在于组织中。在关节炎大鼠模型中，脊髓中吗啡的水平以及吗啡的尿排泄量均有所升高。我们使用从关节炎大鼠脊髓中提取的生物碱样本进行质谱分析，发现分子离子与吗啡和可待因相同。根据内源性吗啡和可待因可能的生理作用对结果进行了讨论。
