Maurice-Williams R S, Kitchen N D
Royal Free Hospital and School of Medicine, London, UK.
Br J Neurosurg. 1994;8(5):519-27. doi: 10.3109/02688699409002944.
The outcome of treatment of 400 consecutive patients with ruptured intracranial aneurysms was assessed at 1 year. The patients were treated by a single surgeon over a period of 13 years. Data sheets completed as each patient was treated included a contemporary analysis of the reasons for any unsatisfactory outcome. Surgery was usually delayed for over 10 days from the last haemorrhage. Over the four successive 100-patient cohorts, in which the composition of the patient population remained unaltered, 1 year overall management mortality fell steadily from 38 to 24%. One year surgical mortality fell from 19 to 3%. The population of those operated on who were in Glasgow Outcome Score 5 at 1 year rose from 73 to 90% (from 51 to 71% for all patients). Of the 123 deaths, 89 occurred prior to operation, 24 after it. Thirty-five patients died from rebleeding prior to operation, but only eight of these occurred in patients judged fit for surgery at the time. All but one of the postoperative deaths resulted from technical problems related to the surgery. Over the successive cohorts, several factors indicated an improvement in operative efficiency, notably a fall in the proportion of cases with technical problems from 15 to 1%. We have demonstrated a steady improvement in management results, resulting largely from increasing operative experience. We do not believe that changes in overall management strategy, such as early surgery, would have any effect on overall outcome.
对400例连续的颅内动脉瘤破裂患者进行了为期1年的治疗结果评估。这些患者由同一位外科医生在13年的时间里进行治疗。在每位患者接受治疗时填写的数据表包括对任何不良结果原因的同期分析。手术通常在最后一次出血后延迟超过10天。在连续的四个100例患者队列中,患者群体的构成保持不变,1年总体管理死亡率从38%稳步下降至24%。1年手术死亡率从19%降至3%。术后1年格拉斯哥预后评分达到5分的手术患者比例从73%升至90%(所有患者从51%升至71%)。在123例死亡病例中,89例发生在手术前,24例发生在手术后。35例患者死于手术前再出血,但其中只有8例发生在当时被判定适合手术的患者中。除1例术后死亡外,其余均因与手术相关的技术问题导致。在连续的队列中,有几个因素表明手术效率有所提高,尤其是技术问题病例的比例从15%降至1%。我们已经证明管理结果稳步改善,这主要得益于手术经验的增加。我们认为,诸如早期手术等总体管理策略的改变不会对总体结果产生任何影响。