Alvarez E O, Banzan A M
Physiol Behav. 1985 May;34(5):661-4. doi: 10.1016/0031-9384(85)90360-9.
The effect of histamine (HA) and 3-methyl-histamine (3-MHA) in the hippocampus on hole-board behavior was studied. Male rats were microinjected stereotaxically into the hippocampus with 1 microliter of saline solution containing 9, 45 or 90 nMol of HA or 3-MHA. Five min later, all rats were tested for 5 min in a hole-board and locomotor, rearing, grooming and head-dipping activities were measured by direct observation. HA inhibited rearing and grooming at all the doses used but it affected locomotor activity only at 45 and 90 nMol doses. There was no effect on head-dipping behavior. 3-MHA instead increased locomotor and head-dipping activities at all the doses used and it did not change rearing and grooming. The present results give a further support for a physiological participation of HA in the hippocampus.
研究了海马体中组胺（HA）和3-甲基组胺（3-MHA）对穿板行为的影响。将雄性大鼠通过立体定位微量注射1微升含有9、45或90纳摩尔HA或3-MHA的盐溶液到海马体中。5分钟后，所有大鼠在穿板装置中接受5分钟测试，通过直接观察测量其运动、竖毛、理毛和探洞活动。HA在所有使用剂量下均抑制竖毛和理毛行为，但仅在45和90纳摩尔剂量下影响运动活动。对探洞行为没有影响。相反，3-MHA在所有使用剂量下均增加运动和探洞活动，且不改变竖毛和理毛行为。目前的结果进一步支持了HA在海马体中的生理参与作用。
