Ogawa T, Mikuni M, Kuroda Y, Muneoka K, Mori K J, Takahashi K
Department of Mental Disorder Research, National Center of Neurology and Psychiatry, Tokyo, Japan.
J Neural Transm Gen Sect. 1994;96(2):113-23. doi: 10.1007/BF01277933.
The aim of the present study is to investigate the effect of neonatal alterations in 5-HT signalling on the regulation of endocrine stress response in adult rats. The neonatal blockade of 5-HT transmission by 5,7-DHT or ritanserin treatment did not alter the density of glucocorticoid receptor (GR) binding sites in the hippocampus, although a 5,7-DHT-induced lesion was clearly shown to decrease in 5-HT content by greater than 80% in the hippocampus. In addition, the animals pretreated with the blockade of 5-HT transmission during early life did not exhibit a hyperresponsiveness of the adrenocortical response to stress. On the other hand, the neonatal administration of the 5-HT uptake inhibitor, clomipramine, was shown to lower the stress responsiveness of the adrenocortical axis in adulthood.
本研究的目的是探讨新生大鼠5-羟色胺（5-HT）信号改变对成年大鼠内分泌应激反应调节的影响。用5,7-二氢麦角隐亭（5,7-DHT）或利坦色林处理对新生大鼠5-HT传递进行阻断，并未改变海马中糖皮质激素受体（GR）结合位点的密度，尽管5,7-DHT诱导的损伤明显显示海马中5-HT含量降低了80%以上。此外，在生命早期接受5-HT传递阻断预处理的动物，其肾上腺皮质对应激的反应并未表现出高反应性。另一方面，新生期给予5-HT摄取抑制剂氯米帕明，可降低成年期肾上腺皮质轴的应激反应性。
