Meaney M J, Aitken D H, Sapolsky R M
Neuroendocrinology. 1987 Apr;45(4):278-83. doi: 10.1159/000124741.
The role of thyroid hormones on the development of intracellular glucocorticoid receptor concentrations was examined in the hippocampus, hypothalamus, and pituitary of the rat. Adult animals, administered triiodothyronine (T3; 1.0 micrograms/g body weight) on days 1, 2, and 4 of life or thyroxine (T4; 2.5 micrograms/g body weight) on days 1 and 2 of life, had significantly elevated glucocorticoid receptor concentrations in the hippocampus, but not in hypothalamus or pituitary. Adult animals treated with propylthiouracil (PTU; 0.2% in the mother's food), a thyroid hormone synthesis inhibitor, for the first 2 weeks of life showed decreased glucocorticoid receptor concentrations in hippocampus, but not in hypothalamus or pituitary. We then examined whether thyroid hormones might mediate the effects of early stimulation on the development of hippocampal glucocorticoid receptor concentrations. Animals that were handled for 15 min daily (Ha) for the first 2 weeks of life showed increased hippocampal glucocorticoid receptor concentrations as adults compared to nonhandled (NHa) controls. PTU administration blocked the effects of handling, such that Ha/PTU animals showed hippocampal glucocorticoid receptor concentrations that were indistinguishable from those of NHa animals. In contrast, corticosterone administration over the first 2 weeks of life had no effect on adult hippocampal glucocorticoid receptor concentrations. These data suggest that thyroid hormones mediate, in part at least, the development of glucocorticoid receptor concentrations in the hippocampus and that this effect occurs independently of their effects on corticosterone titers.
研究了甲状腺激素对大鼠海马体、下丘脑和垂体中细胞内糖皮质激素受体浓度发育的作用。成年动物在出生后第1、2和4天给予三碘甲状腺原氨酸（T3；1.0微克/克体重），或在出生后第1和2天给予甲状腺素（T4；2.5微克/克体重），其海马体中的糖皮质激素受体浓度显著升高，但下丘脑或垂体中则没有。在出生后的前2周用丙硫氧嘧啶（PTU；在母体食物中占0.2%）治疗的成年动物，PTU是一种甲状腺激素合成抑制剂，其海马体中的糖皮质激素受体浓度降低，但下丘脑或垂体中没有。然后，我们研究了甲状腺激素是否可能介导早期刺激对海马体糖皮质激素受体浓度发育的影响。在出生后的前2周每天处理15分钟（Ha）的动物，与未处理（NHa）的对照相比，成年后海马体糖皮质激素受体浓度增加。给予PTU可阻断处理的效果，因此Ha/PTU动物的海马体糖皮质激素受体浓度与NHa动物的无法区分。相比之下，在出生后的前2周给予皮质酮对成年海马体糖皮质激素受体浓度没有影响。这些数据表明，甲状腺激素至少部分介导了海马体中糖皮质激素受体浓度的发育，并且这种作用独立于它们对皮质酮水平的影响而发生。
