对 Geschwind-Behan-Galaburda 模型及布莱登、麦克马纳斯和布尔曼-弗莱明文章的免疫方面的评论。

Comments on immune aspects of the Geschwind-Behan-Galaburda model and of the article of Bryden, McManus, and Bulman-Fleming.

作者信息

St-Marseille A, Braun C M

机构信息

Département de Psychologie, Université du Québec à Montréal, Canada.

出版信息

Brain Cogn. 1994 Nov;26(2):281-90. doi: 10.1006/brcg.1994.1063.

DOI:10.1006/brcg.1994.1063

PMID:7857622

Abstract

The goal of this article is to reconsider the links among immune disorders, testosterone, and left-handedness made originally by Geschwind and Behan (1982) and by Geschwind and Galaburda (1985). We demonstrate that an excess of testosterone in utero is not a prerequisite for immune disorders, because of its destructive action on thymus, and that allergy and autoimmune disorders are not primarily thymo-dependent but B-lymphocyte-dependent. We furthermore study the HLA proposed by Yeo and Gangestad (1993) and retained by Bryden, McManus, and Bulman-Fleming as a possible variable that could explain, in replacement of testosterone, the link among allergy, asthma, and ulcerative colitis. We conclude that the HLA of lefthanders and the meta-analysis of Bryden et al. do not fit together as well as hoped for.

摘要

本文的目的是重新审视最初由 Geschwind 和 Behan（1982 年）以及 Geschwind 和 Galaburda（1985 年）提出的免疫紊乱、睾酮和左利手之间的联系。我们证明，子宫内睾酮过量并非免疫紊乱的先决条件，因为它对胸腺具有破坏作用，而且过敏和自身免疫性疾病并非主要依赖胸腺，而是依赖 B 淋巴细胞。我们还研究了 Yeo 和 Gangestad（1993 年）提出并被 Bryden、McManus 和 Bulman-Fleming 保留的 HLA，它可能是一个变量，可以替代睾酮来解释过敏、哮喘和溃疡性结肠炎之间的联系。我们得出结论，左利手的 HLA 与 Bryden 等人的荟萃分析并不像预期的那样契合。