Mikhail M S, Basu J, Palan P R, Furgiuele J, Romney S L, Anyaegbunam A
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York.
J Assoc Acad Minor Phys. 1995;6(1):43-5.
It has been hypothesized that, in preeclampsia, hypertriglyceridemia may lead to increased endothelial triglyceride accumulation that, in turn, may result in endothelial cell damage. The purpose of our study was to determine whether hypertriglyceridemia is associated with the severity of preeclampsia. We studied 29 preeclamptic patients and 46 normal pregnant women, aged 15 to 35 years, with singleton pregnancies, at 28 to 37 weeks' gestation. Total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were measured enzymatically. High-density lipoprotein cholesterol was determined using a dextran sulfate-magnesium precipitation method. Patients with mild preeclampsia had a significant increase in plasma triglyceride levels (P < .001), while patients with severe preeclampsia had triglyceride levels comparable to controls. Our findings suggest that there is no direct relationship between triglyceride levels and severity of preeclampsia.
有假说认为，在先兆子痫中，高甘油三酯血症可能导致内皮细胞甘油三酯蓄积增加，进而可能导致内皮细胞损伤。我们研究的目的是确定高甘油三酯血症是否与先兆子痫的严重程度相关。我们研究了29例先兆子痫患者和46例年龄在15至35岁之间、单胎妊娠、妊娠28至37周的正常孕妇。采用酶法测定总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平。采用硫酸葡聚糖-镁沉淀法测定高密度脂蛋白胆固醇。轻度先兆子痫患者的血浆甘油三酯水平显著升高（P < .001），而重度先兆子痫患者的甘油三酯水平与对照组相当。我们的研究结果表明，甘油三酯水平与先兆子痫的严重程度之间没有直接关系。
