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偏差溶解:补体溶解活性向未致敏细胞的转移II. 菊粉和抗原抗体复合物产生活性

Deviated lysis: Transfer of complement lytic activity to unsensitized cells II. Generation of the activity by inulin and by antigen antibody complexes.

作者信息

Rother U, Hänsch G, Rother K

出版信息

Z Immunitatsforsch Immunobiol. 1976 Aug;151(1):442-54.

PMID:785847
Abstract

Deviated lysis (d.l.) activity, i.e. lysis of unsensitized cells by lytic C activity, was generated via the classical pathway of Cactivation (ag ab complexes) and via the alternative pathway (inulin). The activity was observed on the surface of the activating particles and in the fluid phase. The activity was relatively stable at 32 degrees C. Its generation involved the C components C6 through C9 and possibly also C5.

摘要

偏离性溶解(d.l.)活性,即通过溶细胞补体(C)活性对未致敏细胞的溶解作用,可通过补体激活的经典途径(抗原-抗体复合物)以及替代途径(菊粉)产生。该活性在激活颗粒表面和液相中均可观察到。在32摄氏度时,该活性相对稳定。其产生涉及补体成分C6至C9,可能还涉及C5。

相似文献

1
Deviated lysis: Transfer of complement lytic activity to unsensitized cells II. Generation of the activity by inulin and by antigen antibody complexes.偏差溶解:补体溶解活性向未致敏细胞的转移II. 菊粉和抗原抗体复合物产生活性
Z Immunitatsforsch Immunobiol. 1976 Aug;151(1):442-54.
2
Deviated lysis: transfer of complement lytic activity to unsensitized cells. I. Generation of the transferable activity on the surface of complement resistant bacteria.偏差溶解:补体溶解活性向未致敏细胞的转移。I. 补体抗性细菌表面可转移活性的产生。
Z Immunitatsforsch Exp Klin Immunol. 1974 Nov;148(2):172-86.
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Deviated lysis: transfer of complement lytic activity to unsensitized cells. IV. Parital isolation of the activity.偏差溶解:补体溶解活性向未致敏细胞的转移。IV. 活性的部分分离。
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Activation of the fifth and sixth component of the complement system: similarities between C5b6 and C(56)a with respect to lytic enhancement by cell-bound C3b or A2C, and species preferences of target cell.补体系统第五和第六成分的激活:C5b6与C(56)a在细胞结合的C3b或A2C介导的溶解增强方面的相似性以及靶细胞的物种偏好
J Immunol. 1981 Sep;127(3):999-1002.
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Deviated lysis (d.l.): III. Kinetics of interaction of d.l. activity with chicken erythrocytes: evidence for E formation.偏差裂解(d.l.):三、d.l.活性与鸡红细胞相互作用的动力学:E形成的证据
Z Immunitatsforsch Immunobiol. 1977 Apr;153(1):36-47.
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Activation of the complement attack mechanism in the fluid phase and its control by C567-INH: lysis of normal erythrocytes initiated by zymosan, endotoxin, and immune complexes.液相中补体攻击机制的激活及其受C567-INH的控制:酵母聚糖、内毒素和免疫复合物引发的正常红细胞溶解。
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Trypsin-activated complex of human factor B with cobra venom factor (CVF), cleaving C3 and C5 and generating a lytic factor for unsensitized guinea pig erythrocytes. I. Generation of the activated complex.人补体B因子与眼镜蛇毒因子(CVF)的胰蛋白酶激活复合物,可裂解C3和C5,并产生针对未致敏豚鼠红细胞的溶血因子。I. 激活复合物的产生。
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Lytic activity of C5-9 complexes for erythrocytes from the species other than sheep: C9 rather than C8-dependent variation in lytic activity.C5 - 9复合物对绵羊以外物种红细胞的溶解活性:溶解活性中依赖C9而非C8的变化。
J Immunol. 1977 Oct;119(4):1482-5.
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Activation of the fifth and sixth components of the human complement system: C6-dependent cleavage of C5 in acid and the formation of a bimolecular lytic complex, C5b,6a.人补体系统第五和第六成分的激活:酸性条件下C6依赖性的C5裂解及双分子溶解复合物C5b,6a的形成
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Complement lysis of human erythrocytes. Differeing susceptibility of two types of paroxysmal nocturnal hemoglobinuria cells to C5b-9.人红细胞的补体溶解。两种阵发性夜间血红蛋白尿细胞对C5b-9的不同敏感性。
J Clin Invest. 1979 Aug;64(2):428-33. doi: 10.1172/JCI109479.

引用本文的文献

1
Interactions of killed Listeria monocytogenes with the mouse complement system.灭活单核细胞增生李斯特菌与小鼠补体系统的相互作用。
Infect Immun. 1981 Oct;34(1):16-9. doi: 10.1128/iai.34.1.16-19.1981.
2
Synthesis of lipids or lipid-containing macromolecules in tumor cells. Relevance to host defense.肿瘤细胞中脂质或含脂质大分子的合成。与宿主防御的相关性。
Surv Immunol Res. 1983;2(2):122-8. doi: 10.1007/BF02918569.
3
C3-independent immune haemolysis: mechanism of membrane attack complex formation.不依赖补体C3的免疫性溶血:膜攻击复合物的形成机制
Immunology. 1986 Sep;59(1):147-51.