Hänsch G, Rother U, Rother K
Z Immunitatsforsch Immunobiol. 1977 Apr;153(1):48-59.
Deviated lysis (d.l.) was previously characterized as the lysis of non-sensitized erythrocytes by activated complement (C) in the presence of EDTA (1, 2, 3). The lytic activity was present in serum fractions of a m.w. in the proximity of 220,000. All the C factors C5 through C9 were found in these fractions and they were all needed for lysis. It is proposed that in d.l. small aggregates of the C components C5 through C9 coexist in the reaction mixture without further interaction. Only when appropriate receptors such as present on target cells surfaces are available, the factors react in a sequential order eventually to result in lysis of the target cell.
偏差溶解（d.l.）以前被定义为在乙二胺四乙酸（EDTA）存在的情况下，活化补体（C）对未致敏红细胞的溶解作用（1, 2, 3）。裂解活性存在于分子量接近220,000的血清组分中。在这些组分中发现了所有C因子（C5至C9），并且它们都是裂解所必需的。有人提出，在偏差溶解中，C5至C9这些补体成分的小聚集体在反应混合物中共存但没有进一步相互作用。只有当诸如靶细胞表面存在的合适受体可用时，这些因子才会按顺序反应，最终导致靶细胞裂解。
