Leaker B, Cairns H S
Institute of Urology and Nephrology, Middlesex Hospital, London.
Br J Hosp Med. 1994;52(10):529-34.
Nephrotoxicity is the most important side effect of cyclosporin therapy. Glomerular filtration rate is reduced in almost all patients and improves when cyclosporin is discontinued. Longterm studies in renal transplant recipients indicate that there is no progressive loss of renal function in the majority of patients treated with cyclosporin. Similar results are found in non-transplant recipients treated with low-dose cyclosporin. Approximately 10% of heart and heart-lung transplant patients develop a progressive deterioration in renal function which may not respond to stopping cyclosporin therapy.
肾毒性是环孢素治疗最重要的副作用。几乎所有患者的肾小球滤过率都会降低，停用环孢素后滤过率会改善。对肾移植受者的长期研究表明，大多数接受环孢素治疗的患者肾功能不会逐渐丧失。在用低剂量环孢素治疗的非移植受者中也发现了类似结果。约10%的心脏和心肺移植患者会出现肾功能进行性恶化，停用环孢素治疗可能对此无反应。
