甘油三酯的碳青霉烯类似物——天然脂质的等排模拟物。用于测定脂肪酶区域选择性和对映体选择性的新型底物。

Carba analogues of triglycerides--isosteric mimics for natural lipids. Novel substrates for the determination of regio- and enantioselectivities displayed by lipases.

作者信息

Berger M, Jakob B, Schneider M P

机构信息

Bergische Universität-GH-Wuppertal, Germany.

出版信息

Bioorg Med Chem. 1994 Jul;2(7):573-88. doi: 10.1016/0968-0896(94)85004-6.

DOI:10.1016/0968-0896(94)85004-6

PMID:7858962

Abstract

The novel carba analogues 1a,b and 2 were synthesized and demonstrated to be isosteric identical mimics for natural triglycerides. They can be used for the system independent determination of regio- and enantioselectivities displayed by lipases. They are, moreover, attractive starting materials for novel carba analogues of phospholipids, PAF analogues and PAF antagonists.

摘要

新型碳环类似物1a、b和2已被合成，并被证明是天然甘油三酯的等排体类似物。它们可用于独立于体系地测定脂肪酶所表现出的区域选择性和对映选择性。此外，它们还是用于合成磷脂的新型碳环类似物、PAF类似物和PAF拮抗剂的有吸引力的起始原料。