睾丸X线照射后的下丘脑-垂体-睾丸系统

Hypothalamic-pituitary-testicular system following testicular X-irradiATION.

作者信息

Verjans H L, Eik-Nes K B

出版信息

Acta Endocrinol (Copenh). 1976 Sep;83(1):190-200. doi: 10.1530/acta.0.0830190.

DOI:10.1530/acta.0.0830190

Abstract

Testes of adult, male rats were exposed to a total dose of 1500 R of X-irradiation. Testicular weight decreased from day 8 after X-ray treatment. This decrease was, however, preceded by an increment of the testis weight on day 4 following treatment. X-ray treatment of testes was associated with significant increases in serum FSH. Testicular irradiation had, however, no effect on ventral prostate and seminal vesicles weights. Serum testosterone increased only on day 1, 2 and 4 after irradiation, while serum LH levels tended to increase from day 8 post-irradiation. These changes were not significant, however, when compared with non-irradiated controls. At 7, 13 and 20 days following 1500 R of bilateral, testicular X-irradiation, the hypothalamic-pituitary unit was still capable of responding to exogenous gonadotrophin releasing factor. Serum FSH may in male rats by regulated at least partly by circulating steroids of testicular origin and partly by an unknown factor of non-interstitial cell nature.

摘要

成年雄性大鼠的睾丸接受了总量为1500拉德的X射线照射。X射线治疗后第8天，睾丸重量开始下降。然而，在治疗后第4天，睾丸重量有一个增加的过程，之后才开始下降。睾丸接受X射线治疗与血清促卵泡激素（FSH）显著升高有关。然而，睾丸照射对腹侧前列腺和精囊重量没有影响。血清睾酮仅在照射后第1、2和4天增加，而血清促黄体生成素（LH）水平在照射后第8天开始有升高趋势。然而，与未照射的对照组相比，这些变化并不显著。在双侧睾丸接受1500拉德X射线照射后的第7、13和20天，下丘脑-垂体单位仍能够对外源性促性腺激素释放因子作出反应。雄性大鼠血清FSH可能至少部分受睾丸来源的循环类固醇调节，部分受非间质细胞性质的未知因子调节。