Pristautz H, Eherer A, Brezinschek R, Truschnig-Wilders M, Petritsch W, Schreiber F, Hammer H F, Wenzl H, Hinterleitner T, Reicht G
Department of Internal Medicine, Karl Franzens University, Graz, Austria.
Endoscopy. 1994 Oct;26(8):690-6. doi: 10.1055/s-2007-1009067.
Eighty-eight endoscopists (mean age 41 years, range 29-76 years) and a control group of 100 persons of similar ages were investigated for the prevalence of antibodies (ABs) to Helicobacter pylori, using a quantitative enzyme-linked immunosorbent assay (ELISA) to IgG, two semiquantitative ELISAs to IgG and IgA, and a latex test to IgG and IgM antibodies. The prevalence of antibodies to H. pylori in endoscopists was 48% (quantitative ELISA), 56% (semiquantitative ELISA to IgG), 62% (latex test), and 57% by combined evaluation of semiquantitative ELISAS to IgG and IgA. The respective numbers in the control group were 47%, 48%, 48% and 51%. None of the differences was significant. In both groups, endoscopists and controls, there was a significantly higher H. pylori positivity in older subjects compared to younger persons, but there was no difference between the two groups. The prevalence of ABs was independent to the number of endoscopies previously performed, and independent of protective measures taken, such as wearing gloves during the procedures. Antibody titers as measured with quantitative ELISA showed a positive correlation with the length of time the subject had been active as an endoscopist, but no correlation with the total number of endoscopies performed. In conclusion, the prevalence of ABs to H. pylori in endoscopists follows the age-dependent pattern known from the general population. The regular performance of gastrointestinal endoscopies poses no additional risk of infection with H. pylori in Austria.
对88名内镜医师（平均年龄41岁，范围29 - 76岁）和100名年龄相仿的对照组人员进行了幽门螺杆菌抗体（ABs）患病率的调查，采用定量酶联免疫吸附测定（ELISA）检测IgG抗体，两种半定量ELISA检测IgG和IgA抗体，以及乳胶试验检测IgG和IgM抗体。内镜医师中幽门螺杆菌抗体的患病率分别为：定量ELISA法48%，IgG半定量ELISA法56%，乳胶试验62%，IgG和IgA半定量ELISA联合评估为57%。对照组的相应数字分别为47%、48%、48%和51%。这些差异均无统计学意义。在内镜医师组和对照组中，老年受试者的幽门螺杆菌阳性率均显著高于年轻受试者，但两组之间无差异。抗体的患病率与之前进行的内镜检查次数无关，也与采取的防护措施（如操作过程中戴手套）无关。定量ELISA检测的抗体滴度与受试者作为内镜医师的工作时长呈正相关，但与内镜检查的总次数无关。总之，内镜医师中幽门螺杆菌抗体的患病率遵循普通人群已知的年龄依赖性模式。在奥地利，定期进行胃肠内镜检查不会增加感染幽门螺杆菌的额外风险。
