Neuhaus H, Hoffmann W, Gottlieb K, Classen M
Department of Medicine II, Technical University of Munich, Klinikum rechts der Isar, Germany.
Gastrointest Endosc. 1994 Nov-Dec;40(6):708-15.
Biliary stones can be removed in 85% to 90% of patients using endoscopic sphincterotomy; in the rest alternative methods are required. Thirty-eight consecutive patients in whom conventional methods had failed underwent laser lithotripsy with a new laser system. A flashlamp-pumped pulsed laser with rhodamine 6G as dye (594 nm) has a tissue-stone recognition system that can identify bile duct stones by analyzing backscattered light and interrupt the pulse in case of tissue contact (Lithognost, Telemit, Munich, Germany). Access of the 0.25- or 0.30-mm-diameter laser fiber to the stones was achieved perorally in 18 patients. In 13 of these cases, eccentrically located stones in the middle or proximal common bile duct were targeted with a 3.4-mm miniscope introduced through a standard duodenoscope. Fluoroscopically guided peroral lithotripsy was performed in 5 patients with stones in the distal common bile duct that could be approached with a standard ERCP catheter. Percutaneous cholangioscopic laser lithotripsy was carried out in 20 patients with stones not amenable to retrograde techniques. The mean number of bile duct stones per patient was 3.6, and the average diameter of the largest stone of each patient was 25 mm (range, 8 to 52 mm). The bile ducts were cleared in all but 1 patient in a mean number of 1.3 sessions lasting 15 to 115 minutes (mean, 60). No laser-related complications were observed. The Lithognost laser was successfully used in 37 of 38 patients referred for the removal of difficult bile duct stones.(ABSTRACT TRUNCATED AT 250 WORDS)
采用内镜括约肌切开术,85%至90%的患者胆管结石能够被取出;其余患者则需要采用其他方法。38例采用传统方法治疗失败的患者接受了一种新型激光系统的激光碎石术。一种以罗丹明6G作为染料的闪光灯泵浦脉冲激光(594纳米)具有组织结石识别系统,该系统可通过分析背向散射光来识别胆管结石,并在接触组织时中断脉冲(Lithognost,Telemit,德国慕尼黑)。18例患者经口将直径0.25毫米或0.30毫米的激光光纤送达结石处。其中13例患者,通过标准十二指肠镜插入3.4毫米微型内镜,对位于胆总管中部或近端的偏心结石进行靶向治疗。5例胆总管远端结石患者,可通过标准ERCP导管接近结石,在荧光镜引导下经口进行碎石术。20例不宜采用逆行技术治疗的结石患者接受了经皮胆管镜激光碎石术。每位患者胆管结石的平均数量为3.6枚,每位患者最大结石的平均直径为25毫米(范围8至52毫米)。除1例患者外,所有患者的胆管结石均在平均1.3次治疗中清除,每次治疗持续15至115分钟(平均60分钟)。未观察到与激光相关的并发症。38例因胆管结石取出困难而转诊的患者中,37例成功使用了Lithognost激光。