Hochberger J, Bayer J, May A, Mühldorfer S, Maiss J, Hahn E G, Ell C
Department of Medicine I, Friedrich Alexander University, Erlangen, Germany.
Gut. 1998 Dec;43(6):823-9. doi: 10.1136/gut.43.6.823.
Laser lithotripsy of bile duct stones has become a widely accepted endoscopic treatment modality for giant, impacted, or very hard stones. The procedure is usually carried out under direct endoscopic control in view of the potential risk of bile duct injuries in "blind" laser application.
To investigate the use of a rhodamine 6G laser lithotriptor with an integrated optical stone tissue detection system (oSTDS).
From 1 September 1991 to 7 March 1997, 60 patients with giant or impacted common bile duct stones refractory to endoscopic papillotomy stone extraction, and mechanical lithotripsy were treated via the endoscopic retrograde route using a rhodamine 6G dye laser (595 nm, 2.5 micros, 80-150 mJ pp, Lithognost Telemit/Baasel Corp., Germany) with integrated oSTDS. In case of tissue contact oSTDS cuts off the laser pulse after 190 ns (transmission of 5-8% of the total pulse energy). 47 patients (78.3%) were subjected to x ray targeting (oSTDS) alone, five (8.3%) to choledochoscope targeting alone, and eight (13.3%) to both techniques.
At the end of treatment 52 (87%) patients were completely stone-free. The only major complications included transient haemobilia, cholangitis, and pancreatitis in five patients. All five were successfully treated by conservative methods.
Laser lithotripsy using the described rhodamine 6G dye laser with oSTDS seems to be safe and effective and allows "blind" fragmentation of difficult common bile duct stones under radiological control only.
胆管结石的激光碎石术已成为一种广泛接受的内镜治疗方式,用于治疗巨大、嵌顿或非常坚硬的结石。鉴于“盲目”激光应用存在胆管损伤的潜在风险,该手术通常在内镜直接控制下进行。
研究一种集成光学结石组织检测系统(oSTDS)的罗丹明6G激光碎石器的应用。
从1991年9月1日至1997年3月7日,60例经内镜乳头切开取石术及机械碎石术治疗无效的巨大或嵌顿性胆总管结石患者,通过内镜逆行途径,使用集成oSTDS的罗丹明6G染料激光(595nm,2.5微秒,80 - 150mJ脉冲峰值,德国巴塞尔公司Lithognost Telemit)进行治疗。一旦组织接触,oSTDS在190纳秒后切断激光脉冲(传输总脉冲能量的5 - 8%)。47例患者(78.3%)仅接受X线定位(oSTDS),5例(8.3%)仅接受胆管镜定位,8例(13.3%)接受两种技术。
治疗结束时,52例(87%)患者结石完全清除。仅有的主要并发症包括5例患者出现短暂性胆道出血、胆管炎和胰腺炎。所有5例均通过保守方法成功治疗。
使用所述的带有oSTDS的罗丹明6G染料激光进行激光碎石术似乎安全有效,仅在放射学控制下即可对困难的胆总管结石进行“盲目”破碎。