Collet D, Chastan P, Rabaud M
Service de Chirurgie Digestive, CHU de Bordeaux.
J Chir (Paris). 1994 Nov;131(11):478-82.
Endopatch E-F is a new product elaborated with natural human and animal proteins. Its synthesis originates in a covalent link between elastin and fibrin monomers. Numerous experimental studies carried out in animal have previously shown its ability to reinforce healing process of digestive wall. The results reported herein have been obtained in very selected patients in whom a digestive anastomosis had to be done in spite of unfavorable circumstances, such as intra-abdominal infection, radiated bowel or ascitis. From October 1990 to October 1992, 21 digestive anastomosis have been performed in 18 patients. All were reinforced by Endopatch E-F. Two deaths have been observed (mortality: 11.1%), which do not look like a consequence of the use of the product (One myocardial infarction and one cirrhotic failure). There were 2 post-operative fistulas (9.5% of the whole anastomosis). No patients had any reaction of intolerance. These preliminary results confirm experimental data, and suggest that Endopatch EF can be used in order to reinforce digestive sutures when performed under unfavorable circumstances.
Endopatch E-F是一种由天然人类和动物蛋白质制成的新产品。它通过弹性蛋白和纤维蛋白单体之间的共价连接合成。先前在动物身上进行的大量实验研究表明，它有能力加强消化壁的愈合过程。本文报告的结果是在经过严格挑选的患者身上获得的，这些患者尽管处于不利的情况下，如腹腔内感染、放射性肠病或腹水，但仍必须进行消化吻合术。从1990年10月到1992年10月，对18例患者进行了21次消化吻合术。所有手术均使用Endopatch E-F进行加强。观察到2例死亡（死亡率：11.1%），这似乎并非该产品使用的后果（1例心肌梗死和1例肝硬化衰竭）。有2例术后瘘（占全部吻合术的9.5%）。没有患者出现任何不耐受反应。这些初步结果证实了实验数据，并表明在不利情况下进行消化缝合时，Endopatch EF可用于加强缝合。
