Drenda P, Lampe P, Górka Z, Bursig H, Dylag S
Kliniki Chirurgii Przewodu Pokarmowego Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 1997;50 Suppl 1 Pt 2:252-6.
The goal of this study is evaluation in experimental and clinical circumstances of biological dressings obtained form lyophilized human placenta and chitosan. The therapeutic specificities of human placenta where confirmed in the course many years' observation in The Department of Surgery of the Digestive Tract. The reservation arose only because of inconvenience in using placenta fragile after lyophilization. The product was obtained in the course of studies which were performed in common with The Chemical Fibres Institute in Lódź. This product (which was a combination of placenta and chitosan) was free of defects considering defects of lyophilized placenta. The experimental part of study was performed on 50 female rats of Wistar strain. It was compared healing of wound 2 cm2 area provided with tested dressing and the other controlled wound. The result was evaluated on the ground of postoperative survival and the macroscopic and microscopic evaluation. In the clinical part of the study the experimental model was made by wounds provided by sutures passed by all layers on special "small drains" which under drains make bedsores placed symmetrically on both sides of incision line. The evaluation was performed randomly putting on one of these sides of tested dressing. There was evaluated the speed of demarcation, growth of granulation tissue and epithelialization. The evaluation was compared with standard dressing. Combination of therapeutic specificities of lyophilized human placenta with proper mechanical specificities of chitosan made possible to obtain comfortable and efficient dressing. In the clinical part of the study on the ground of macroscopic evaluation it was found that the process of the healing in tested group becomes shorter of about 48 hours.
本研究的目的是在实验和临床环境中评估从冻干人胎盘和壳聚糖获得的生物敷料。在消化道外科多年的观察过程中证实了人胎盘的治疗特异性。唯一的问题是冻干后胎盘易碎，使用不便。该产品是在与罗兹化学纤维研究所共同进行的研究过程中获得的。考虑到冻干胎盘的缺陷，该产品（胎盘和壳聚糖的组合）没有缺陷。研究的实验部分在50只Wistar品系雌性大鼠身上进行。比较了用测试敷料处理的2平方厘米面积伤口和另一个对照伤口的愈合情况。根据术后存活率以及宏观和微观评估结果进行评价。在研究的临床部分，通过在特殊的“小引流管”上穿过所有层的缝线造成伤口来建立实验模型，在引流管下方形成对称放置在切口线两侧的褥疮。随机在其中一侧使用测试敷料进行评估。评估了分界速度、肉芽组织生长和上皮形成情况。并与标准敷料进行比较。冻干人胎盘的治疗特异性与壳聚糖适当的机械特异性相结合，使得获得舒适且有效的敷料成为可能。在研究的临床部分，根据宏观评估发现，测试组的愈合过程缩短了约48小时。
