Devor E J
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City 52242-1057.
J Consult Clin Psychol. 1994 Dec;62(6):1108-15. doi: 10.1037//0022-006x.62.6.1108.
The research for biological-genetic markers of alcoholism is discussed in the context of a multifactorial, heterogeneous, developmental model of the disease. It is suggested that the strategies used in both linkage and association studies require modification to accommodate this more complex model. It is also suggested that several extant associations of genetic markers with alcoholism represent true secondary interactive phenomena that alter the outcome of primary alcoholism genotypes at the phenotype level.
本文在酒精中毒多因素、异质性、发展模型的背景下，探讨了酒精中毒生物学-遗传标记物的研究。研究表明，连锁研究和关联研究中使用的策略需要进行修改，以适应这种更为复杂的模型。研究还表明，遗传标记物与酒精中毒之间目前存在的几种关联代表了真正的继发性交互作用现象，这些现象在表型水平上改变了原发性酒精中毒基因型的结果。
