Warfvinge G, Larsson A
Department of Oral Pathology, Lund University, Malmö, Sweden.
J Oral Pathol Med. 1994 Nov;23(10):441-5. doi: 10.1111/j.1600-0714.1994.tb00441.x.
Light microscopy and immunocytochemistry have been used to study the tissue reaction to non-irritant concentrations of mercury painted onto the oral mucosa of genetically mercury-sensitive BN rats. Low-dose skin injections of HgCl2 in BN rats result in an autoimmune syndrome, including also a spontaneous migration of T lymphocytes into the oral mucosa. Our results show that such infiltrates confer an increased degree of reactivity (contact stomatitis) to HgCl2 painted onto the BN (Hg) rat oral mucosa. In contrast, results were negative in the LEW rat strain, which is also resistant to development of autoimmunity to skin-injected mercury. The possible involvement of mucosal mercury-loaded macrophages is discussed. The results are also discussed with respect to possible etiologic and pathogenetic mechanisms involved in the development of dental material (amalgam)-associated lichenoid lesions of human oral mucosa.
利用光学显微镜和免疫细胞化学技术，研究了遗传性汞敏感的BN大鼠口腔黏膜涂抹无刺激性浓度汞后的组织反应。给BN大鼠低剂量皮下注射氯化汞会导致自身免疫综合征，其中还包括T淋巴细胞自发迁移至口腔黏膜。我们的研究结果表明，这种浸润会使涂抹在BN（汞）大鼠口腔黏膜上的氯化汞的反应程度（接触性口炎）增加。相比之下，LEW大鼠品系的结果为阴性，该品系对皮肤注射汞引发的自身免疫也具有抗性。文中讨论了黏膜中负载汞的巨噬细胞可能发挥的作用。还就人类口腔黏膜中与牙科材料（汞合金）相关的苔藓样病变发展过程中可能涉及的病因和发病机制对研究结果进行了讨论。
