与油田废弃物场地相关的系统性红斑狼疮（SLE）聚集：一项横断面研究
Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study.
作者信息
Dahlgren James, Takhar Harpreet, Anderson-Mahoney Pamela, Kotlerman Jenny, Tarr Jim, Warshaw Raphael
机构信息
Department of Occupational and Environmental Medicine, UCLA School of Medicine, Los Angeles, CA, USA.
出版信息
Environ Health. 2007 Feb 22;6:8. doi: 10.1186/1476-069X-6-8.
BACKGROUND
This is a community comparison study that examines persons living in a subdivision exposed to petroleum products and mercury.
METHODS
We compared their health status and questionnaire responses to those living in another community with no known exposures of this type.
RESULTS
Pristane house dust among the exposed homes was higher than in the comparison communities. The exposed subdivision has higher ambient air mercury levels compared to the control community. The prevalence of rheumatic diseases (OR = 10.78; CI = 4.14, 28.12) and lupus (OR = 19.33; CI = 1.96, 190.72) was greater in the exposed population compared to the unexposed. A higher prevalence of neurological symptoms, respiratory symptoms and several cardiovascular problems including stroke (OR = 15.41; CI = 0.78, 304.68) and angina (OR = 5.72; CI = 1.68, 19.43) was seen.
CONCLUSION
There were statistically significant differences in B cells, Natural Killer Cells, gamma glutamyl transferase, globulin and serum calcium levels between control and exposed subjects.
背景
这是一项社区比较研究，调查居住在一个接触石油产品和汞的分区中的人群。
方法
我们将他们的健康状况和问卷调查结果与另一个无此类已知接触情况的社区居民进行比较。
结果
接触组家庭中的降姥鲛烷房屋灰尘高于对照社区。与对照社区相比，接触组分区的环境空气中汞含量更高。与未接触人群相比，接触人群中风湿性疾病（比值比 = 10.78；可信区间 = 4.14，28.12）和狼疮（比值比 = 19.33；可信区间 = 1.96，190.72）的患病率更高。观察到神经症状、呼吸道症状以及包括中风（比值比 = 15.41；可信区间 = 0.78，304.68）和心绞痛（比值比 = 5.72；可信区间 = 1.68，19.43）在内的几种心血管问题的患病率更高。
结论
对照组和接触组受试者在B细胞、自然杀伤细胞、γ-谷氨酰转移酶、球蛋白和血清钙水平上存在统计学显著差异。
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