Rump S, Faff J, Szymańska T, Bak W, Borkowska G
Arch Toxicol. 1976 Aug 18;35(4):275-80. doi: 10.1007/BF00570269.
The effectiveness of repeated pharamacotherapy in acute poisonings with fluostigmine was studied in rats. It was demonstrated, that the second i.p. administration of obidoxime (40 mg/kg) was without effect. Repeated i.p. administration of atropine (10 mg/kg) shown marked efficacy only in animals treated previously with atropine (10 mg/kg) and diazepam (2.5 mg/kg). This procedure was without effect in animals treated just after intoxication with atropine (10 mg/kg) or atropine (10 mg/kg) and obidoxime (40 mg/kg). Subsequent administration of diazepam (2.5 mg/kg) or caramiphen (10 mg/kg) was without effect.
在大鼠中研究了反复药物治疗氟斯的明急性中毒的有效性。结果表明，第二次腹腔注射双复磷（40毫克/千克）无效。反复腹腔注射阿托品（10毫克/千克）仅在先前用阿托品（10毫克/千克）和地西泮（2.5毫克/千克）治疗的动物中显示出显著疗效。该程序对中毒后立即用阿托品（10毫克/千克）或阿托品（10毫克/千克）和双复磷（40毫克/千克）治疗的动物无效。随后给予地西泮（2.5毫克/千克）或卡拉美芬（10毫克/千克）无效。
