抗惊厥药物在有机磷中毒中的治疗价值。
Therapeutic value of anticonvulsant drugs in poisonings with an organophosphate.
作者信息
Grudzińska E, Gidyńska T, Rump S
出版信息
Arch Int Pharmacodyn Ther. 1979 Apr;238(2):344-50.
PMID:383032
Abstract
Therapeutic effects of phenytoin, pentobarbital, diazepam, trimethadione and phensuximide given as an adjuvant to atropine and obidoxime in fluostigmine intoxication were studied in the rat. It was stated that only trimethadione significantly elevated the LD50 value for fluostigmine in animals treated with atropine and obidoxime. None of the tested anticonvulsants raised the LD10 value above the LD90 value in animals treated only with atropine and obidoxime.
摘要
研究了苯妥英、戊巴比妥、地西泮、三甲双酮和甲琥胺作为辅助药物与阿托品和双复磷联合使用对大鼠氟斯的明中毒的治疗效果。结果表明，在使用阿托品和双复磷治疗的动物中，只有三甲双酮显著提高了氟斯的明的半数致死量（LD50）值。在仅用阿托品和双复磷治疗的动物中，所测试的抗惊厥药均未使10%致死量（LD10）值高于90%致死量（LD90）值。
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