Puckett T R, Peele K A, Howard R S, Kramer K K
Department of Ophthalmology, Winn Army Community Hospital, Ft. Stewart, Georgia.
Ophthalmology. 1995 Feb;102(2):291-6. doi: 10.1016/s0161-6420(95)31026-3.
Two intraocular irrigating solutions which differ principally by the presence of oxidized glutathione were compared in this randomized, masked, prospective study to discern differences in preservation of endothelial cell size.
Sixty-four patients undergoing extracapsular cataract extractions were randomized between two irrigating solution groups, Balanced Salt Solution (BSS) Plus (n = 30) and dextrose bicarbonate lactated Ringer's solution (n = 34). Preoperative and postoperative endothelial specular photomicrographs were analyzed for cell size and hexagonality, and the two groups were compared using repeated measures analysis of variance.
Fifty-eight subjects (91%) completed the 2-month study. Change in cell size for the BSS Plus group (n = 28) (mean +/- standard error, 29.4 +/- 12.3 microns2) was not significantly different from the dextrose bicarbonate lactated Ringer's solution group (n = 30) (27.5 +/- 12.9 microns2) (P = 0.92). Groups did not differ significantly in percent hexagonality (P = 0.57) or in the variability of cell size (P = 0.61).
The presence of glutathione in BSS Plus and other minor electrolyte differences between the solutions is not more advantageous with regard to endothelial cell size than dextrose bicarbonate lactated Ringer's solution for standard extracapsular cataract surgery. Cost per 500-microliters bottle of BSS plus is $62 compared with $9.80 for dextrose bicarbonate lactated Ringer's solution.
在这项随机、双盲、前瞻性研究中，比较了两种主要因氧化型谷胱甘肽的存在而不同的眼内冲洗液，以辨别内皮细胞大小保存方面的差异。
64例行白内障囊外摘除术的患者被随机分为两组冲洗液组，平衡盐溶液（BSS）加组（n = 30）和葡萄糖碳酸氢盐乳酸林格氏液组（n = 34）。对术前和术后的内皮细胞镜面显微镜照片进行细胞大小和六边形度分析，并使用重复测量方差分析对两组进行比较。
58名受试者（91%）完成了为期2个月的研究。BSS加组（n = 28）（平均±标准误，29.4±12.3平方微米）的细胞大小变化与葡萄糖碳酸氢盐乳酸林格氏液组（n = 30）（27.5±12.9平方微米）无显著差异（P = 0.92）。两组在六边形度百分比（P = 0.57）或细胞大小变异性（P = 0.61）方面无显著差异。
对于标准白内障囊外手术，BSS加液中谷胱甘肽的存在以及溶液之间的其他微小电解质差异在内皮细胞大小方面并不比葡萄糖碳酸氢盐乳酸林格氏液更具优势。每500微升瓶装BSS加液的成本为62美元，而葡萄糖碳酸氢盐乳酸林格氏液为9.80美元。
