Dringenberg H C, Kornelsen R A, Vanderwolf C H
Neuroscience Program, University of Western Ontario, London, Canada.
Pharmacol Biochem Behav. 1994 Nov;49(3):741-6. doi: 10.1016/0091-3057(94)90095-7.
The effects of the putative anxiolytic agent buspirone on food-handling behavior of laboratory rats were investigated. Rats trained to travel from a covered shelter to a food source were provided with food pellets of six sizes. Smaller pellets were eaten at the exposed food source, whereas larger pellets were carried back to the shelter for consumption. Subcutaneous administration of buspirone hydrochloride (0.2-2.0 mg/kg) reduced carrying of larger food pellets in a dose-dependent manner. Instead, these pellets were also eaten at the exposed food source. Carrying was maximally suppressed 1 h after drug administration. Handling of smaller pellets, travel times, and eating times were not affected by buspirone. Similar results have previously been obtained with diazepam. Buspirone appears to exert its effects through 5-HT1A and/or dopamine receptors, whereas diazepam interacts with benzodiazepine receptors. Thus, manipulations of distinct transmitter systems may have similar behavioral consequences on the food carrying responses of rats.
研究了假定的抗焦虑药物丁螺环酮对实验大鼠食物处理行为的影响。训练大鼠从有盖的庇护所前往食物源，并为其提供六种大小的食物颗粒。较小的颗粒在暴露的食物源处被吃掉，而较大的颗粒则被带回庇护所食用。皮下注射盐酸丁螺环酮（0.2 - 2.0毫克/千克）以剂量依赖的方式减少了对较大食物颗粒的搬运。相反，这些颗粒也在暴露的食物源处被吃掉。给药后1小时，搬运行为受到最大程度的抑制。丁螺环酮对较小颗粒的处理、行进时间和进食时间没有影响。之前使用地西泮也得到了类似的结果。丁螺环酮似乎通过5 - HT1A和/或多巴胺受体发挥作用，而地西泮则与苯二氮䓬受体相互作用。因此，对不同递质系统的操控可能对大鼠的食物搬运反应产生相似的行为后果。
