Torres C, Morales A, Cándido A, Maldonado A
Departamento de Psicología Experimental y Fisiología del Comportamiento, Universidad de Granada, Spain.
Eur J Pharmacol. 1995 Jul 14;280(3):277-84. doi: 10.1016/0014-2999(95)00210-c.
The main aim of the present work was to investigate the effect of buspirone, a 5-HT1A receptor agonist, on successive negative contrast in one-way avoidance learning. Successive negative contrast was induced by shifting rats from a large reward (30 s spent in the safe compartment) to a small reward (1 s). Acute administration of buspirone (0.25, 0.5, 0.75 and 1.0 mg/kg i.p.) did not attenuate the contrast effect, as opposed to that observed for diazepam (1 mg/kg i.p.). The highest dose of buspirone used, however, did interfere with the learning of the avoidance response itself. Chronic buspirone (20 days, 0.5 and 0.75 mg/kg i.p.) did not have any effect on successive negative contrast either. Overall, these results could suggest that the 5-HT1A receptor is not involved in the negative contrast effect studied, quite different to that observed for the gamma-aminobutyric acid (GABA) system. The findings are compared to results obtained with animal models selectively sensitive to some anxiolytic drugs, as are the so-called 'conflict models'.
本研究的主要目的是探讨5-羟色胺1A受体激动剂丁螺环酮对单向回避学习中相继负性对比的影响。通过将大鼠从大奖励（在安全隔室中停留30秒）转换为小奖励（1秒）来诱导相继负性对比。与地西泮（腹腔注射1mg/kg）的作用相反，丁螺环酮（腹腔注射0.25、0.5、0.75和1.0mg/kg）的急性给药并未减弱对比效应。然而，所使用的丁螺环酮最高剂量确实干扰了回避反应本身的学习。慢性给予丁螺环酮（20天，腹腔注射0.5和0.75mg/kg）对相继负性对比也没有任何影响。总体而言，这些结果可能表明5-羟色胺1A受体不参与所研究的负性对比效应，这与γ-氨基丁酸（GABA）系统的情况截然不同。将这些研究结果与在对某些抗焦虑药物敏感的动物模型（即所谓的“冲突模型”）中获得的结果进行了比较。
