Tanda G, Carboni E, Frau R, Di Chiara G
Department of Toxicology, University of Cagliari, Italy.
Psychopharmacology (Berl). 1994 Jun;115(1-2):285-8. doi: 10.1007/BF02244785.
Drugs differing in their primary mechanism of action but having in common the ability to act as antidepressants such as fluoxetine (10 mg/kg SC), clomipramine (10 mg/kg IP), imipramine (10 mg/kg IP), desipramine (10 mg/kg IP) and (+/-) 8-OHDPAT (0.03 mg/kg SC) increase extracellular concentrations of dopamine in the rat prefrontal cortex but not in the medial nucleus accumbens. Buspirone (1 mg/kg SC) increased dopamine both in the prefrontal cortex and in the nucleus accumbens. Extracellular 5HT was increased by fluoxetine, clomipramine and imipramine but not by desipramine while 8-OHDPAT and buspirone decreased it. These results raise the possibility that the property of stimulating dopamine transmission in the prefrontal cortex has a role in the antidepressant properties of these drugs.
作用机制不同但都具有抗抑郁作用的药物，如氟西汀（10毫克/千克，皮下注射）、氯米帕明（10毫克/千克，腹腔注射）、丙咪嗪（10毫克/千克，腹腔注射）、地昔帕明（10毫克/千克，腹腔注射）和（±）8-羟基二丙胺基四氢吡啶（0.03毫克/千克，皮下注射），可增加大鼠前额叶皮质细胞外多巴胺浓度，但伏隔核内侧的浓度未增加。丁螺环酮（1毫克/千克，皮下注射）可增加前额叶皮质和伏隔核中的多巴胺浓度。氟西汀、氯米帕明和丙咪嗪可增加细胞外5-羟色胺浓度，而地昔帕明则无此作用，8-羟基二丙胺基四氢吡啶和丁螺环酮则降低细胞外5-羟色胺浓度。这些结果提示，刺激前额叶皮质多巴胺传递的特性在这些药物的抗抑郁特性中起作用。
