Di Chiara G, Tanda G, Frau R, Carboni E
Department of Toxicology, University of Cagliari, Italy.
Psychopharmacology (Berl). 1993;112(2-3):398-402. doi: 10.1007/BF02244939.
Concentric dialysis probes were vertically implanted in rats in the nucleus accumbens (Acc) of one side and in the dorsal caudate-putamen (CPu) of the other side. On the day after the implant the output of dopamine was monitored and the changes elicited by d-amphetamine sulphate were compared in the two areas. Amphetamine preferentially stimulated dopamine release in the Acc in a wide range of doses (0.25, 0.5, 1.0, 2.0 mg/kg SC) when Acc probes were located in the medial aspect of the Acc. In contrast, no significant differences between the Acc and the dorsal CPu were obtained in response to amphetamine (0.5 mg/kg SC) when Acc probes were located about 0.7 mm lateral to the previous site. It is concluded that the preferential effect of amphetamine in the Acc is related to precise topographical boundaries. This in turn might be related to the existence of a sharp anatomical and functional heterogeneity within the Acc.
将同心透析探针垂直植入大鼠体内，一侧植入伏隔核（Acc），另一侧植入背侧尾状核-壳核（CPu）。植入后的第二天，监测多巴胺的输出，并比较这两个区域中硫酸右旋苯丙胺引起的变化。当Acc探针位于Acc内侧时，苯丙胺在广泛的剂量范围（0.25、0.5、1.0、2.0 mg/kg皮下注射）内优先刺激Acc中的多巴胺释放。相比之下，当Acc探针位于先前位置外侧约0.7 mm处时，对苯丙胺（0.5 mg/kg皮下注射）的反应在Acc和背侧CPu之间未获得显著差异。得出的结论是，苯丙胺在Acc中的优先作用与精确的地形边界有关。这反过来可能与Acc内存在明显的解剖学和功能异质性有关。
