Mitchell D G, Outwater E K, Matteucci T, Rubin D L, Chezmar J L, Saini S
Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA.
Radiology. 1995 Mar;194(3):783-7. doi: 10.1148/radiology.194.3.7862979.
To determine adrenal gland enhancement with manganese (II) N,N' dipyridoxylethylenediamine-N,N'-diacetate 5,5'bis(phosphate) (DPDP) at magnetic resonance imaging.
After phase III trials, fat-suppressed, motion-compensated, T1-weighted spin-echo images (repetition time, 500 msec; echo time, 12 msec) of 13 consecutive patients were obtained at 1.5 T at one site, prior to and approximately 30 minutes after intravenous administration of 5 mumol/kg Mn-DPDP. Images were analyzed visually and by means of region-of-interest measurements, normalized to spleen. With data added from three more sites, enhancement of three adrenal adenomas and two metastases was analyzed.
Twenty-five of 26 adrenal glands were depicted on MR images, and all showed enhancement. Mean adrenal enhancement (38%) was comparable to mean enhancement of liver (46%), pancreas (25%), and renal cortex (58%). Adrenal cortex and medulla could not be distinguished in nonenhanced or enhanced images. All three adrenal adenomas enhanced by more than 40%, but the metastases did not enhance.
Functioning adrenal tissue (glands and at least some adenomas) are enhanced with Mn-DPDP.
在磁共振成像中确定使用锰（II）N，N'-二吡啶氧乙基二胺-N，N'-二乙酸盐5，5'-双（磷酸盐）（DPDP）时肾上腺的强化情况。
在III期试验后，在一个部位对13例连续患者于静脉注射5 μmol/kg Mn-DPDP之前及大约30分钟后，在1.5 T磁场下获取脂肪抑制、运动补偿的T1加权自旋回波图像（重复时间，500毫秒；回波时间，12毫秒）。图像通过视觉分析并采用感兴趣区测量法，以脾脏为标准进行归一化处理。加入另外三个部位的数据后，分析了三个肾上腺腺瘤和两个转移瘤的强化情况。
26个肾上腺中的25个在磁共振图像上显示出来，且均有强化。肾上腺平均强化率（38%）与肝脏（46%）、胰腺（25%）和肾皮质（58%）的平均强化率相当。在未强化或强化图像中，肾上腺皮质和髓质无法区分。所有三个肾上腺腺瘤强化超过40%，但转移瘤未强化。
功能性肾上腺组织（腺体及至少部分腺瘤）在使用Mn-DPDP时会强化。
