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Development of F-18-labeled fluoroerythronitroimidazole as a PET agent for imaging tumor hypoxia.

作者信息

Yang D J, Wallace S, Cherif A, Li C, Gretzer M B, Kim E E, Podoloff D A

机构信息

Division of Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston 77030.

出版信息

Radiology. 1995 Mar;194(3):795-800. doi: 10.1148/radiology.194.3.7862981.

DOI:10.1148/radiology.194.3.7862981
PMID:7862981
Abstract

PURPOSE

To develop a hydrophilic ligand to image tumor hypoxia at positron emission tomography (PET).

MATERIALS AND METHODS

Biodistribution of fluorine-18-labeled fluoroerythronitroimidazole (FETNIM) and F-18-labeled fluoromisonidazole (FMISO) was determined at PET and autoradiography in three mammary-tumor-bearing rats. The partition coefficient of FETNIM, FMISO, and misonidazole was determined.

RESULTS

Biodistribution of F-18-labeled FETNIM at 1, 2, and 4 hours showed tumor-to-blood ratios of 2.29 +/- 0.599, 2.41 +/- 0.567 and 8.02 +/- 2.420, respectively, and tumor-to-muscle ratios of 0.66 +/- 0.267, 2.11 +/- 0.347, and 5.92 +/- 2.240, respectively. The tumor-to-blood count density ratio with F-18-labeled FETNIM at 4 hours after injection was significantly higher than with F-18-labeled FMISO. Autoradiographs indicated that both agents could help differentiate hypoxic versus necrotic region in the tumor.

CONCLUSION

F-18-labeled FETNIM can help detect tumor hypoxia and is easier to prepare, less costly, and more hydrophilic than F-18-labeled FMISO.

摘要

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