Iakhno N N, Damulin I V, Chernenko O A, Ianakaeva T A, Kondrat'eva O N, Kur'ianova P T
Ter Arkh. 1994;66(10):10-2.
The activity of myorelaxant sirdalud (tizanidine) was studied in 36 patients aged 20-79 with pain syndrome (reflex muscular-tonic, myofascial, acute compression radiculopathy). The condition of the patients was evaluated according to the visual analog scale where the scores were assigned to the intensity of muscular spasm, pain at rest, exercise and at altitude tension and functional decline. Pain symptoms diminished as early as the treatment day 3. The same was true for muscular spasms. The highest effect of sirdalud occurred in acute phases of the diseases. Pain relief was so material that 20 patients were able to discontinue analgetics and tranquilizers. For 12 patients the doses of nonsteroid antiinflammatory drugs were noticeably reduced. Side effects of sirdalud were minimal: slight sleepiness and xerostomia.
对36名年龄在20至79岁之间患有疼痛综合征（反射性肌肉紧张、肌筋膜性、急性压迫性神经根病）的患者进行了肌松药西乐葆（替扎尼定）的活性研究。根据视觉模拟量表对患者的病情进行评估，该量表根据肌肉痉挛强度、静息痛、运动痛、高度紧张时的疼痛以及功能衰退情况进行评分。早在治疗第3天，疼痛症状就有所减轻。肌肉痉挛情况也是如此。西乐葆在疾病的急性期效果最佳。疼痛缓解非常显著，以至于20名患者能够停用镇痛药和镇静剂。对于12名患者，非甾体抗炎药的剂量明显减少。西乐葆的副作用极小：轻微嗜睡和口干。
