• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

肿瘤杂交细胞产生的对主要组织相容性抗原的无限制T细胞介导的细胞毒性。

Unrestricted T cell-mediated cytotoxicity to major histocompatibility antigen generated with tumor hybrid cells.

作者信息

Kambe M, Tachibana T

机构信息

Department of Clinical Oncology, Tohoku University, Sendai.

出版信息

Tohoku J Exp Med. 1994 Sep;174(1):85-93. doi: 10.1620/tjem.174.85.

DOI:10.1620/tjem.174.85
PMID:7863506
Abstract

Splenic T cells from C3H/He mice injected with the LFM3A#2 hybrid cells intraperitoneally (i.p.) showed cytotoxic activity against the parental FM3A/R tumor cells. We studied the target antigens recognized by cytotoxic T cells (CTL) and the following results were obtained. 1) CTL specifically recognized the MM antigens on the surface of target cells in effector phase. 2) The H-2K or H-2D antigens were not involved in T cell effector function.

摘要

经腹腔注射LFM3A#2杂交细胞的C3H/He小鼠的脾T细胞，对亲代FM3A/R肿瘤细胞表现出细胞毒性活性。我们研究了细胞毒性T细胞（CTL）识别的靶抗原，并获得了以下结果。1）CTL在效应阶段特异性识别靶细胞表面的MM抗原。2）H-2K或H-2D抗原不参与T细胞效应功能。

相似文献

1
Unrestricted T cell-mediated cytotoxicity to major histocompatibility antigen generated with tumor hybrid cells.肿瘤杂交细胞产生的对主要组织相容性抗原的无限制T细胞介导的细胞毒性。
Tohoku J Exp Med. 1994 Sep;174(1):85-93. doi: 10.1620/tjem.174.85.
2
Differences in immune responses to tumor induced in syngeneic hosts by injection of hybrid and parental tumor cells.
Tohoku J Exp Med. 1994 Sep;174(1):71-83. doi: 10.1620/tjem.174.71.
3
T lymphocyte responses to multiple minor histocompatibility antigens generate both self-major histocompatibility complex-restricted and cross-reactive cytotoxic T lymphocytes.T淋巴细胞对多种次要组织相容性抗原的反应会产生自身主要组织相容性复合体限制的和交叉反应性细胞毒性T淋巴细胞。
Transplantation. 1994 Jul 15;58(1):59-67.
4
Secondary in vitro generation of CTL specific for MM antigen by stimulation with somatic tumor hybrid, but not with parental tumor cells.
J Immunol. 1983 Oct;131(4):2059-63.
5
Recognition of Rous sarcoma virus-induced tumor antigens by cytotoxic T lymphocytes (CTL): studies on specificity of killing by CTL employing H-2 congenic and recombinant mouse tumor cells.细胞毒性T淋巴细胞（CTL）对劳氏肉瘤病毒诱导的肿瘤抗原的识别：利用H-2同源和重组小鼠肿瘤细胞对CTL杀伤特异性的研究。
Cell Immunol. 1987 Apr 1;105(2):340-54. doi: 10.1016/0008-8749(87)90082-7.
6
Induction and characterization of minor histocompatibility antigens. Specific primary cytotoxic T lymphocyte responses in vitro.次要组织相容性抗原的诱导与特性。体外特异性原发性细胞毒性T淋巴细胞反应。
J Immunol. 1988 Feb 1;140(3):723-9.
7
Augmentation of syngeneic tumor-specific immunity by semiallogeneic cell hybrids.半同种异体细胞杂交增强同基因肿瘤特异性免疫。
J Immunol. 1983 Jun;130(6):2982-6.
8
Role of major and minor histocompatibility antigens in the suppression of alloreactive cytotoxic responses induced by alloantigen pretreatment.主要和次要组织相容性抗原在同种抗原预处理诱导的同种异体反应性细胞毒性反应抑制中的作用。
Res Immunol. 1990 Nov-Dec;141(9):839-53. doi: 10.1016/0923-2494(90)90184-z.
9
Protection against metastasis by immunization with an allogeneic lymphocyte antigen.通过同种异体淋巴细胞抗原免疫来预防转移。
Cancer Immunol Immunother. 1995 Dec;41(6):384-8. doi: 10.1007/BF01526558.
10
The target minor H antigen for F1 cytotoxic T lymphocytes induced by Igh-congenic parental spleen cells is coded for by gene linked to H-2.由同基因亲本脾脏细胞诱导的F1细胞毒性T淋巴细胞的靶次要组织相容性抗原由与H-2相关的基因编码。
J Immunol. 1985 May;134(5):2953-9.