长春地辛对下丘脑-垂体-肾上腺轴的影响。
Effects of vindesine on hypothalamic-pituitary-adrenal axis.
作者信息
Brunetti L, Preziosi P, Ragazzoni E, Vacca M
机构信息
Department of Pharmacology and Pharmacognosy, G. D'Annunzio University, Chieti, Italy.
出版信息
Toxicol Lett. 1995 Jan;75(1-3):69-73. doi: 10.1016/0378-4274(94)03162-z.
Vindesine, a cell-cycle-specific agent currently employed in the treatment of some neoplasias, was able to produce a remarkable dose-dependent adrenocortical activation, but it was unable to increase plasma corticosterone in hypophysectomized rats in vivo. In addition, vindesine was able to increase ACTH release in vitro when tested on isolated pituitary cells in culture suggesting a direct involvement of the pituitary gland in the increase of adrenal secretion in vivo.
长春地辛是一种目前用于治疗某些肿瘤的细胞周期特异性药物，它能够产生显著的剂量依赖性肾上腺皮质激活，但在体内对垂体切除的大鼠却无法增加血浆皮质酮水平。此外，当在培养的分离垂体细胞上进行测试时，长春地辛能够在体外增加促肾上腺皮质激素（ACTH）的释放，这表明垂体在体内肾上腺分泌增加过程中直接发挥了作用。
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