每日单次剂量苯妥英钠控制癫痫
Control of epilepsy with a single daily dose of phenytoin sodium.
作者信息
Cocks D A, Critchley E M
出版信息
Br J Clin Pharmacol. 1975 Oct;2(5):449-53. doi: 10.1111/j.1365-2125.1975.tb00555.x.
Fifty-three patients in an epileptic centre have been studied. All were receiving phenytoin and many were also receiving other antoconvulsant drugs. 2. Thirty-six patients took part in a three month cross over study. There was no significant change in the frequency of epileptic seizures or in the late morning serum concentration of phenytoin when the treatemtn was changed from two to three spaced doses of phenytoin sodium/day to a single dose at 12.00 hours. 3. Seventeen patients acted as a control group. They received phenytoin sodium as two or three spaced doses/day throughout the study. There was no significant change in the frequency of epileptic seizures or in the late morning serum concentration of phenytoin between the first and second three month periods of observation. 4. It is concluded that the total daily dose of phenytoin sodium may be given once daily without reduction of the anticonvulsant effect.
对一家癫痫中心的53名患者进行了研究。所有患者都在服用苯妥英钠，许多患者还在服用其他抗惊厥药物。2. 36名患者参与了一项为期三个月的交叉研究。当治疗方案从每天分两次或三次服用苯妥英钠改为中午12点单次服药时，癫痫发作频率和上午晚些时候的苯妥英钠血清浓度均无显著变化。3. 17名患者作为对照组。在整个研究过程中，他们每天分两次或三次间隔服用苯妥英钠。在第一个和第二个三个月的观察期之间，癫痫发作频率和上午晚些时候的苯妥英钠血清浓度均无显著变化。4. 得出的结论是，苯妥英钠的每日总剂量可以每天服用一次，而不会降低抗惊厥效果。
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