苯妥英钠与丙戊酸盐在既往未治疗的成年癫痫患者中的比较。
A comparison of phenytoin and valproate in previously untreated adult epileptic patients.
作者信息
Turnbull D M, Rawlins M D, Weightman D, Chadwick D W
出版信息
J Neurol Neurosurg Psychiatry. 1982 Jan;45(1):55-9. doi: 10.1136/jnnp.45.1.55.
Abstract
Eighty-eight patients with the onset of epilepsy in adult life were randomly allocated to treatment with sodium valproate (600 mg/day), or phenytoin (300 mg/day), and followed up for at least 12 months. Both drugs were highly effective in the control of tonic-clonic seizures, irrespective of whether they were accompanied by focal features, but were markedly less effective in the control of partial seizures. Two patients exhibited acute allergic reactions to phenytoin. No significant differences have yet emerged in the efficacy of the two drugs, and valproate may be considered as a "fist-line" anticonvulsant in the treatment of adult onset epilepsy.
摘要
88例成年期起病的癫痫患者被随机分配接受丙戊酸钠（600毫克/天）或苯妥英钠（300毫克/天）治疗，并随访至少12个月。两种药物在控制强直阵挛性发作方面均非常有效，无论是否伴有局灶性特征，但在控制部分性发作方面明显效果较差。两名患者对苯妥英钠出现急性过敏反应。两种药物的疗效尚未出现显著差异，丙戊酸钠可被视为治疗成年期起病癫痫的“一线”抗惊厥药物。
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2
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3
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