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[梗死早期的冠状动脉内介入治疗]

[Intracoronary interventions in the early infarct period].

作者信息

Meyer J

机构信息

II. Medizinische Klinik und Poliklinik der Johannes-Gutenberg-Universität, Mainz.

出版信息

Z Kardiol. 1994;83 Suppl 6:111-9.

PMID:7863683
Abstract

Despite that intravenous thrombolysis can be regarded as the routine treatment of acute myocardial infarction, alternative or additive interventional procedures in some situations may be well indicated. Primary dilatation without preceding thrombolysis, introduced by G. Hartzler, has shown significantly better results in mortality, re-infarction rate, reduction of coronary stenoses, and improvement of ejection fraction compared to thrombolysis in several randomized studies. The procedure, however, is based on expensive logistics and very experienced operators. In patients with evident failure of lysis, large infarctions, depressed left ventricular function, and cardiogenic shock, rescue-PTCA is indicated. If it is performed early this intervention shows good acute and late results. The elective dilatation of residual stenoses after successfull thrombolysis is performed only in selected cases. Its main indication is proven ischemia within the first days and weeks after onset of infarction. Early cardiac surgery is performed in patients with cardiogenic shock, papillary or septum rupture, and with cardiac tamponade. Good results can also be expected in main stem stenoses and severe multivessel diseases. The optimal time of surgery, however, is still controversial. The Task Force of the International Society and Federation of Cardiology (IFSC) and the World Health Organization (WHO) has worked out recommendations for intracoronary maneuvers in various situations of the acute phase of myocardial infarction. With thoughtful consideration of indications these additional procedures in the hands of experienced teams play an important role in the acute treatment of this severe disease.

摘要

尽管静脉溶栓可被视为急性心肌梗死的常规治疗方法,但在某些情况下,替代或辅助性的介入治疗手段可能也很有必要。G. 哈茨勒提出的在不进行溶栓的情况下直接进行扩张术,在多项随机研究中显示,与溶栓相比,在死亡率、再梗死率、冠状动脉狭窄程度的减轻以及射血分数的改善方面都有显著更好的效果。然而,该手术需要昂贵的后勤保障和经验丰富的操作人员。对于溶栓明显失败、大面积梗死、左心室功能低下以及心源性休克的患者,应进行补救性经皮冠状动脉腔内血管成形术(PTCA)。如果早期进行该干预,会显示出良好的近期和远期效果。仅在特定病例中对成功溶栓后的残余狭窄进行选择性扩张。其主要指征是在梗死发作后的头几天和几周内证实存在缺血。对于心源性休克、乳头肌或室间隔破裂以及心脏压塞的患者,应尽早进行心脏手术。对于主干狭窄和严重多支血管病变,也可预期有良好效果。然而,手术的最佳时机仍存在争议。国际心脏病学会和联合会(IFSC)以及世界卫生组织(WHO)的特别工作组已经制定了在心肌梗死急性期各种情况下进行冠状动脉内操作的建议。在经验丰富的团队手中,经过深思熟虑地考虑适应证后,这些额外的治疗手段在这种严重疾病的急性治疗中发挥着重要作用。

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