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[重症监护中的机械心脏辅助系统]

[Mechanical cardiac assist systems in intensive care].

作者信息

Figulla H R, Scholz K H

机构信息

Abteilung Kardiologie und Pulmonologie, Universitäts-Kliniken, Göttingen.

出版信息

Z Kardiol. 1994;83 Suppl 6:97-109.

PMID:7863708
Abstract

The indications for the use of mechanical cardiac assist-devices are sudden death, cardiogenic shock, severe coronary ischemia and high-risk PTCA. Among the cardiac assist-devices, currently available for cardiologists and cardiac surgeons, are the Intraaortal Balloon Pump (IABP), the implantable turbine-pump, the percutaneous cardiopulmonary support (PCPS), centrifugal pumps which are connected via a thoracotomy and intra- and extrathoracic total artificial hearts. It is easy to position the IABP, which can be continuously used over the course of several days. In the case of cardiogenic shock, the pump should be implanted as soon as possible, in order to facilitate revascularisation procedure in a patient with ischemic heart disease. By this procedures the survival rate of ischemic cardiogenic shock has been raised from 20% to 60%. However, the IABP does not prove supportive in the case of an MI without shock or in high-risk PTCA. The implantable turbine pump (Hemopump TM) is available in 3 configurations, ranging in external size from 14 F to 26 F. Of these, only the 14 F pumps can be implanted percutaneously by a Seldinger technique, whereas the bigger pumps require arteriotomy or thoracotomy for placement. The pump-rates of these systems reach from 2.0 l/min to 4.5 l/min. These pumps are used in high-risk PTCA as well as CABG-surgery without cardiopulmonary support, but are still currently in a test phase. However, at this point, it is still too early to finally evaluate the clinical importance of these systems. The percutaneous cardiopulmonary support (PCPS) has a major advantage over all other assist device systems, as it completely replaces the circulation. Therefore, PCPS is especially indicated in cardiac arrest, because it can be inserted very quickly, even without having to interrupt resuscitation. A second indication is high-risk PTCA, where it can be used also as a stand-by system. A study with 801 patients, investigating the use of this system in high-risk PTCA, resulted in a hospital mortality of 6.9%. In therapy-resistant circulatory arrest, approximately 30% of patients could be saved with this system, provided that there is a very quick access to it, as there is for example in the cardiac cath lab. Centrifugal pumps, which are inserted via a thoracotomy, and artificial hearts have become very important and are now used routinely in cardiac surgery to support patients, who have developed therapy-refractory heart failure, and in transplantation-surgery as "bridging to transplant". These systems, however, bear the complications of hemorrhage and thromboembolism.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

使用机械心脏辅助装置的指征包括猝死、心源性休克、严重冠状动脉缺血和高危经皮冠状动脉腔内血管成形术(PTCA)。在目前心脏病专家和心脏外科医生可使用的心脏辅助装置中,有主动脉内球囊反搏泵(IABP)、植入式涡轮泵、经皮心肺支持(PCPS)、通过开胸连接的离心泵以及胸内和胸外全人工心脏。IABP易于放置,可连续使用数天。在心源性休克的情况下,应尽快植入该泵,以便于对缺血性心脏病患者进行血管重建手术。通过这种手术,缺血性心源性休克的存活率已从20%提高到60%。然而,IABP在无休克的心肌梗死或高危PTCA情况下并无支持作用。植入式涡轮泵(Hemopump TM)有3种型号,外部尺寸从14F到26F不等。其中,只有14F的泵可通过Seldinger技术经皮植入,而较大型号的泵需要切开动脉或开胸来放置。这些系统的泵速可达2.0升/分钟至4.5升/分钟。这些泵用于高危PTCA以及无体外循环支持的冠状动脉旁路移植术(CABG)手术,但目前仍处于试验阶段。然而,此时最终评估这些系统的临床重要性仍为时过早。经皮心肺支持(PCPS)相对于所有其他辅助装置系统具有一个主要优势,即它能完全替代循环。因此,PCPS特别适用于心脏骤停,因为它可非常快速地插入,甚至无需中断复苏。第二个指征是高危PTCA,在这种情况下它也可作为备用系统。一项对801例患者进行的研究,调查了该系统在高危PTCA中的使用情况,结果显示医院死亡率为6.9%。在治疗无效的循环骤停中,如果能像在心脏导管室那样非常快速地使用该系统,大约30%的患者可通过此系统获救。通过开胸插入的离心泵和人工心脏已变得非常重要,现在在心脏手术中常规用于支持已出现治疗难治性心力衰竭的患者,以及在移植手术中作为“过渡到移植”的手段。然而,这些系统存在出血和血栓栓塞的并发症。(摘要截断于400字)

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