Deie M, Ochi M, Ikuta Y
Department of Orthopedics, Hiroshima University School of Medicine, Japan.
Acta Orthop Scand. 1995 Feb;66(1):28-32. doi: 10.3109/17453679508994634.
We studied the intrinsic healing capacity of human semitendinosus tendon specimens, comparing them to human anterior cruciate ligament specimens collected at the time of ligament reconstructions, and using an organ culture model. On the day after cultivation, migration of cells and synthesis of collagen fibers were observed in the ligament group with preserved synovium (PS), the ligament group with resected synovium (RS), and the semitendinosus tendon group (ST). Migrating cells and newly-formed collagen fibers were most prominent in the PS group, followed by the RS, and ST groups. When the area occupied by the migrating cells and newly-formed collagen fibers in the prepared hole was measured, no differences were observed between the groups at week 2. However, differences were noted between the ST and PS or RS groups at weeks 4 and 6. Our findings indicate that the human anterior cruciate ligament possesses a high intrinsic healing capacity. It is also suggested that the synovium plays an important role in enhancing ligament healing capacity.
我们研究了人半腱肌肌腱标本的内在愈合能力，将其与韧带重建时采集的人前交叉韧带标本进行比较，并使用器官培养模型。培养后第二天，在保留滑膜的韧带组（PS）、切除滑膜的韧带组（RS）和半腱肌肌腱组（ST）中均观察到细胞迁移和胶原纤维合成。迁移细胞和新形成的胶原纤维在PS组中最为显著，其次是RS组和ST组。当测量制备孔中迁移细胞和新形成胶原纤维所占面积时，第2周各组之间未观察到差异。然而，在第4周和第6周，ST组与PS组或RS组之间存在差异。我们的研究结果表明，人前交叉韧带具有较高的内在愈合能力。还表明滑膜在增强韧带愈合能力方面起重要作用。
