一些新型3-(2-N,N-二烷基氨基乙基)-吡啶并[2,3-d]嘧啶-4-酮的合成及药理性质
Synthesis and pharmacological properties of some new 3-(2-N,N-dialkylaminoethyl)-pyrido [2,3-d]-pyrymidin-4-ones.
作者信息
Kowalska T, Kowalski P, Rutkowski K, Woźniak M, Kleinrok Z, Jagiełło-Wójtowicz E, Szurska G, Chodkowska A
机构信息
Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków.
出版信息
Acta Pol Pharm. 1994;51(2):143-8.
The following new derivatives of pyrido [2,3-d]-pyrimidin-4(3H)-one were synthesized: 3-(2-N,N-dimethylaminoethyl), 3-(2-N-pyrolidynylethyl), 3-(2-piperidinylethyl) and 3-(2-N-morpholidinylethyl). Their chemical structures were confirmed by MS, IR and 1H NMR spectroscopic data. Newly synthesized compounds were investigated pharmacologically for their central properties in mice and rats. It was shown that compound [III] showed anxiolytic action in the four-plate test and two compounds produced analgesic effects in mice.
合成了以下新型吡啶并[2,3 - d] - 嘧啶 - 4(3H) - 酮衍生物：3 - (2 - N,N - 二甲基氨基乙基)、3 - (2 - N - 吡咯烷基乙基)、3 - (2 - 哌啶基乙基)和3 - (2 - N - 吗啉代乙基)。通过质谱、红外光谱和1H核磁共振光谱数据确认了它们的化学结构。对新合成的化合物进行了药理研究，考察其对小鼠和大鼠的中枢作用。结果表明，化合物[III]在四板试验中表现出抗焦虑作用，两种化合物对小鼠产生镇痛效果。
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