预期对中枢神经系统有抑制活性的 3H-吡啶并[2,3-d]嘧啶-4-酮的吡啶乙烯基衍生物的合成。第一部分。
Synthesis of pyridylethenyl derivatives of 3H-pyrido[2,3-d]-pyrimidyn-4-on of expected depressive activity on central nervous system. Part I.
作者信息
Herold F, Gutkowska B, Baranowski A, Kałucka M, Helbin E
机构信息
Department of Drug Technology, School of Medicine, Warsaw, Poland.
出版信息
Acta Pol Pharm. 1994;51(3):257-62.
PMID:7872018
Abstract
Synthesis of 2-(pyridylethenyl) derivatives of 3H-pyrido[2,3-d]pyrimidin-4-on [Va-k] by condensation of selected 2-methyl-3H-pyrido[2,3-d]pyrimidin-4-ones [IVa-k] with nicotinic aldehyde is described. Compounds [Vh] and [Vi] showed weak analgetic activities.
摘要
描述了通过选定的2-甲基-3H-吡啶并[2,3-d]嘧啶-4-酮[IVa-k]与烟醛缩合合成3H-吡啶并[2,3-d]嘧啶-4-酮[Va-k]的2-（吡啶基亚乙烯基）衍生物。化合物[Vh]和[Vi]表现出微弱的镇痛活性。
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