作为白血病防御机制的骨髓移植遗传抗性
Genetic resistance to marrow transplantation as a leukemia defense mechanism.
作者信息
Gallagher M T, Lotzová E, Trentin J J
出版信息
Biomedicine. 1976 Feb 10;25(1):1-3.
(C57 X AKR) F1 hybrid mice show genetic resistance to C57 parental bone marrow cells, but not to AKR parental bone marrow cells. (C3H X AKR) F1 hybrids show no genetic resistance to bone marrow transplantation from either parental strain. Transplantation of AKR lymphoma cells into lethally irradiated "resistant" (C57 X AKR) F1 and "non-resistant" (C3H X AKR) F1 hybrids produce lymphomatous spleen colonies in "non-resistant" hybrids but not in "resistant" hybrids. Thus "resistant" (C57 X AKR) F1 hybrids can recognize and reject AKR lymphoma cells, but not normal AKR bone marrow cells. A normal biological role of lymphoma surveillance is postulated for genetic resistance.
（C57×AKR）F1杂种小鼠对C57亲代骨髓细胞表现出遗传抗性，但对AKR亲代骨髓细胞则没有抗性。（C3H×AKR）F1杂种对来自任一亲本品系的骨髓移植均无遗传抗性。将AKR淋巴瘤细胞移植到经致死剂量照射的“抗性”（C57×AKR）F1和“非抗性”（C3H×AKR）F1杂种小鼠中，“非抗性”杂种小鼠会产生淋巴瘤性脾集落，而“抗性”杂种小鼠则不会。因此，“抗性”（C57×AKR）F1杂种小鼠能够识别并排斥AKR淋巴瘤细胞，但不能识别并排斥正常的AKR骨髓细胞。推测淋巴瘤监测的正常生物学作用与遗传抗性有关。
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