首发精神病患者的颞叶质子磁共振波谱分析
Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis.
作者信息
Renshaw P F, Yurgelun-Todd D A, Tohen M, Gruber S, Cohen B M
机构信息
McLean Brain Imaging Center, McLean Hospital, Belmont, MA 02178.
出版信息
Am J Psychiatry. 1995 Mar;152(3):444-6. doi: 10.1176/ajp.152.3.444.
OBJECTIVE
The authors measured the ratio of N-acetyl aspartate (a putative neuronal marker) to creatine-phosphocreatine in patients with first-episode psychosis by using proton magnetic resonance spectroscopy (MRS).
METHOD
Temporal lobe 1H MRS was performed bilaterally on 13 patients with first-episode psychosis and 15 comparison subjects. The N-acetyl aspartate/creatine-phosphocreatine and choline/creatine-phosphocreatine ratios were determined.
RESULTS
The N-acetyl aspartate/creatine-phosphocreatine ratio of the psychotic patients was significantly lower than that of the comparison subjects.
CONCLUSIONS
These preliminary data suggest that abnormalities in temporal lobe N-acetyl aspartate concentration are present early in psychotic illness.
目的
作者通过质子磁共振波谱法（MRS）测量首发精神病患者中N-乙酰天门冬氨酸（一种假定的神经元标志物）与磷酸肌酸的比率。
方法
对13例首发精神病患者和15名对照受试者双侧进行颞叶1H MRS检查。测定N-乙酰天门冬氨酸/磷酸肌酸和胆碱/磷酸肌酸比率。
结果
精神病患者的N-乙酰天门冬氨酸/磷酸肌酸比率显著低于对照受试者。
结论
这些初步数据表明，颞叶N-乙酰天门冬氨酸浓度异常在精神病早期就已存在。
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