Descamps J L
Ann Pharm Fr. 1994;52(6):294-302.
Technical developments of genetic engineering have been revealed especially interesting in the human therapeutic field. Techniques for gene transfer have been improved to introduce synthetic sequences into the cellular genomes. Candidate cells and culture systems have been screened for their capacity to synthesise the proper recombinant molecules. In the nearest future, high biotechnologies should provide a great quantity of recombinant products, covering a high variety of diseases (clotting factors, cytokines, hormones, monoclonal antibodies, vaccines, thrombolytics). This tendency has been largely initiated, and is accompanied by the quick development of basic sciences such as glycobiology and molecular biology, together with the development of a specific regulatory environment. Besides, genetic engineering offers new therapeutic outlets: transgenic animals, genic therapy, antisense technology.
基因工程的技术发展在人类治疗领域已显示出特别的吸引力。基因转移技术已得到改进，以便将合成序列引入细胞基因组。已筛选候选细胞和培养系统，以评估它们合成合适重组分子的能力。在不久的将来，高科技应能提供大量的重组产品，涵盖多种疾病（凝血因子、细胞因子、激素、单克隆抗体、疫苗、溶栓剂）。这种趋势已在很大程度上启动，并伴随着糖生物学和分子生物学等基础科学的迅速发展，以及特定监管环境的发展。此外，基因工程提供了新的治疗途径：转基因动物、基因治疗、反义技术。
