Russell R R
Department of Oral Biology, Dental School, University of Newcastle, Newcastle upon Tyne, UK.
Adv Dent Res. 1994 Jul;8(2):285-90. doi: 10.1177/08959374940080022301.
The Specific Plaque Hypothesis posits that particular bacteria are of unique importance in the etiology of dental caries and periodontal diseases, and a logical conclusion is that these bacteria should be the targets for our 'magic bullets' in devising plaque-control methods. This paper considers the development of preventive measures based on understanding of the significance of particular bacterial species and the properties of those bacteria. Knowledge of the importance of specific organisms as mediators of disease and molecular studies on the properties of potential virulence factors may reveal potential targets for inhibition, blocking by synthetic analogues, or functional inactivation by antibodies.
特异性菌斑假说认为，特定细菌在龋齿和牙周疾病的病因学中具有独特的重要性，由此得出的一个合乎逻辑的结论是，在设计菌斑控制方法时，这些细菌应该成为我们“神奇子弹”的目标。本文基于对特定细菌种类的重要性及其特性的理解，探讨了预防措施的发展。了解特定生物体作为疾病介质的重要性以及对潜在毒力因子特性的分子研究，可能会揭示出抑制、通过合成类似物阻断或通过抗体使其功能失活的潜在靶点。
