静脉注射多巴胺不能改变大鼠肾上腺髓质的功能。
I. c. v. dopamine fails to alter adrenomedullary function in rats.
作者信息
Kujacic M, Carlsson A
机构信息
Department of Pharmacology, University of Göteborg, Sweden.
出版信息
J Neural Transm Gen Sect. 1994;95(3):235-40. doi: 10.1007/BF01271569.
Intracerebroventricularly (i.c.v.) administered dopamine (50-400 micrograms/kg, 30 min; 400 micrograms/kg, 2 and 4 h) did not induce statistically significant changes in heart adrenaline (presumed to represent the adrenaline release from the adrenals). Only the highest dose (400 micrograms/kg, 30 min) brought about significant increase in adrenal dopamine (reflecting the catecholamine synthesis), accompanied by increase in heart dopamine, indicating leakage of dopamine into the peripheral circulation. The results did not support involvement of the central dopamine receptors in the short-term control of the adrenomedullary function in rats.
脑室内（i.c.v.）注射多巴胺（50 - 400微克/千克，30分钟；400微克/千克，2小时和4小时）并未引起心脏肾上腺素（推测代表肾上腺释放的肾上腺素）出现统计学上的显著变化。只有最高剂量（400微克/千克，30分钟）导致肾上腺多巴胺显著增加（反映儿茶酚胺合成），同时心脏多巴胺增加，表明多巴胺漏入外周循环。结果不支持中枢多巴胺受体参与大鼠肾上腺髓质功能的短期调控。
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