Vesalainen S, Lipponen P, Talja M, Syrjänen K
Department of Surgery, University of Kuopio, Finland.
Acta Oncol. 1995;34(1):53-9. doi: 10.3109/02841869509093639.
The serum levels of creatinine (CR), alkaline phosphatase (ALP), acid phosphatase (ACP) and tartrate inhibitable acid phosphatase (TIAP) were related to Gleason score, TM-category, disease progression and survival in 325 prostatic adenocarcinoma patients followed up for over 12 years. Elevated serum levels of CR, ALP, ACP and TIAP were related to invasive and metastatic disease as well as with a high Gleason score. Elevated serum levels of CR, ALP, ACP and TIAP, all significantly predicted prognosis in a univariate analysis. In the M0 tumours, ACP and TIAP and TIAP had prognostic value, as they did in the T1-2M0 tumours respectively. Cox's multivariate analysis showed that serum creatinine level at diagnosis had independent prognostic value additional to the TM-classification, Gleason score and patient age. In the M0 tumours, ALP had independent prognostic significance additional to the T-category, Gleason score and patient age. In the T1-2M0 tumours, TIAP had independent prognostic value supplementary to the Gleason score, T-category and patient age, whereas in the T1M0 tumours, the gleason score was an independent prognostic parameter. The results indicate that these simple laboratory tests give important prognostic information in prostatic adenocarcinoma.
对325例随访超过12年的前列腺腺癌患者，血清肌酐（CR）、碱性磷酸酶（ALP）、酸性磷酸酶（ACP）和抗酒石酸酸性磷酸酶（TIAP）水平与Gleason评分、TM分期、疾病进展及生存相关。血清CR、ALP、ACP和TIAP水平升高与侵袭性和转移性疾病以及高Gleason评分相关。在单因素分析中，血清CR、ALP、ACP和TIAP水平升高均显著预测预后。在M0肿瘤中，ACP和TIAP分别在T1-2M0肿瘤中具有预后价值。Cox多因素分析显示，诊断时的血清肌酐水平除TM分期、Gleason评分和患者年龄外具有独立的预后价值。在M0肿瘤中，ALP除T分期、Gleason评分和患者年龄外具有独立的预后意义。在T1-2M0肿瘤中，TIAP除Gleason评分、T分期和患者年龄外具有独立的预后价值，而在T1M0肿瘤中，Gleason评分是独立的预后参数。结果表明，这些简单的实验室检查可为前列腺腺癌提供重要的预后信息。
