Silman A J, Newman J
ARC Epidemiology Research Unit, University of Manchester, UK.
Curr Opin Rheumatol. 1994 Nov;6(6):607-11. doi: 10.1097/00002281-199411000-00010.
Recent epidemiologic research on scleroderma has been directed toward both genetic and environmental factors. The nature of any genetic contribution is unknown, although the major histocompatibility complex region is important in determining antibody response. Environmentally, an occupational basis in a small proportion of cases seems likely. There is no evidence to support the hypothesis that silicone gel breast implants are an important risk factor in the development of scleroderma.
近期关于硬皮病的流行病学研究聚焦于遗传和环境因素。尽管主要组织相容性复合体区域在决定抗体反应方面很重要，但任何遗传因素的具体性质尚不清楚。在环境方面，一小部分病例似乎可能存在职业因素。没有证据支持硅胶乳房植入物是硬皮病发病的重要危险因素这一假设。
