Walden J A, Stevenson L W, Dracup K, Hook J F, Moser D K, Hamilton M, Fonarow G C
Division of Cardiology, University of California, Los Angeles.
J Heart Lung Transplant. 1994 Nov-Dec;13(6):1109-18.
Heart failure has been associated with poor quality of life, which can improve after heart transplantation. Long-term quality-of-life comparisons between patients with heart failure stabilized with medical therapy and heart transplant recipients have not been performed. We assessed quality of life at the time of heart transplantation evaluation and again after 41 months in 12 patients with advanced heart failure stabilized with medical therapy and in 19 patients who had gone on to undergo heart transplantation. Quality of life was measured by three questionnaires. Both groups had similar quality-of-life and clinical features during the transplantation evaluation. Over time, feelings of anxiety and depression, psychologic adaptation, and perceived functional capability improved in the transplant recipients. However, transplant recipients reported more weakness after surgery; this was the major symptom that limited activities. At follow-up 41 months later, we found no significant differences in quality-of-life changes over time between patients stabilized with medical therapy and heart transplant recipients. Overall quality of life for patients who remain stable while receiving medical therapy may not be significantly different from patients who have undergone transplantation.
心力衰竭与生活质量差相关，心脏移植后生活质量可得到改善。尚未对通过药物治疗病情稳定的心力衰竭患者与心脏移植受者的长期生活质量进行比较。我们评估了12例通过药物治疗病情稳定的晚期心力衰竭患者和19例已接受心脏移植的患者在心脏移植评估时以及41个月后的生活质量。生活质量通过三份问卷进行测量。两组在移植评估期间具有相似的生活质量和临床特征。随着时间的推移，移植受者的焦虑和抑郁情绪、心理适应能力以及感知功能能力均有所改善。然而，移植受者术后报告虚弱感更强；这是限制活动的主要症状。在41个月后的随访中，我们发现通过药物治疗病情稳定的患者与心脏移植受者在生活质量随时间变化方面无显著差异。接受药物治疗病情保持稳定的患者的总体生活质量可能与接受移植的患者没有显著差异。
