新生儿细菌感染四项检测的比较研究。总中性粒细胞计数、C反应蛋白、纤维蛋白原和C3d。
Comparative study of four tests of bacterial infection in the neonate. Total neutrophil count, CRP, fibrinogen and C3d.
作者信息
Guillois B, Donnou M D, Sizun J, Bendaoud B, Youinou P
机构信息
Service de Réanimation Pédiatrique et de Néonatalogie, Centre Hospitalier Régional et Universitaire de Brest, France.
出版信息
Biol Neonate. 1994;66(4):175-81. doi: 10.1159/000244105.
In a prospective study, the diagnostic value of C3d serum levels was compared with that of neutropenia, hyperfibrinogenemia and raised CRP in generalized neonatal bacterial infections. Serum C3d was evaluated using a counter-immunoelectrophoresis technique following a step of removal of C3 split products. Twelve patients with septicemia, 8 patients with highly probable infection and 134 normal controls were included in the study. The sensitivities for neutropenia, hyperfibrinogenemia, raised CRP and positive C3d were 21, 45, 60 and 70%, respectively, with a significant difference between the sensitivities of neutropenia and positive C3d (p < 0.01). The specificities were found to be 99.2, 99.2, 100 and 97.7% respectively. Thus the C3d qualitative test appears to be as reliable as CRP in the diagnosis of neonatal bacterial infections.
在一项前瞻性研究中，比较了C3d血清水平与中性粒细胞减少、高纤维蛋白原血症及C反应蛋白升高在新生儿全身性细菌感染中的诊断价值。在去除C3裂解产物后，采用对流免疫电泳技术评估血清C3d。该研究纳入了12例败血症患者、8例高度疑似感染患者及134例正常对照。中性粒细胞减少、高纤维蛋白原血症、C反应蛋白升高及C3d阳性的敏感性分别为21%、45%、60%和70%，中性粒细胞减少与C3d阳性的敏感性之间存在显著差异（p<0.01）。特异性分别为99.2%、99.2%、100%和97.7%。因此，C3d定性检测在新生儿细菌感染诊断中似乎与C反应蛋白一样可靠。
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