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Intergeniculate leaflet ablation alters circadian rhythms in the mouse.

作者信息

Pickard G E

机构信息

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104-6141.

出版信息

Neuroreport. 1994 Oct 27;5(16):2186-8. doi: 10.1097/00001756-199410270-00049.

DOI:10.1097/00001756-199410270-00049
PMID:7865773
Abstract

The intergeniculate leaflet (IGL) receives retinal input and sends afferents to the hypothalamic suprachiasmatic nucleus (SCN), a circadian oscillator. The effect of IGL ablation on the circadian rhythm of wheel-running activity was examined in mice maintained in constant dark (DD) and in two intensities of constant light (LL). IGL-lesioned animals demonstrated significantly longer free-running rhythms in DD conditions than IGL-intact mice similarly housed; there was no effect of IGL ablation on the period of the free-running activity rhythm in LL of either 10 or 100 lux intensity. A change in the period of the free-running activity rhythm in DD following IGL destruction is evidence that the IGL exerts an endogenous influence on the SCN circadian system.

摘要

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